Primary genetic disorders affecting high density lipoprotein (HDL)
نویسندگان
چکیده
منابع مشابه
Lipoproteomics Environmental and Genetic Factors Affecting High-Density Lipoprotein (HDL)
To my wife Therese For being my unwavering friend and companion on this journey. I wouldn´t be here today without You Abstract Lipoprotein particles act as lipid transporters in the blood stream, and measuring cholesterol content in specific subclasses of lipoprotein particles has long been, and still is, a frequently used tool to estimate the risk of cardiovascular disease (CVD). High-density ...
متن کاملThe role of level and function of High Density Lipoprotein (HDL) in Cardiovascular Diseases
High-density lipoprotein (HDL) is a set of particles with heterogeneous structures that have different functions due to various compounds including surface charge, size, lipid, and protein compounds. Several prospective epidemiological studies have demonstrated that there is a clear inverse relationship between serum HDL concentration and risk of coronary heart disease, despite this relationshi...
متن کاملMendelian disorders of high-density lipoprotein metabolism.
High-density lipoproteins (HDLs) are a highly heterogeneous and dynamic group of the smallest and densest lipoproteins present in the circulation. This review provides the current molecular insight into HDL metabolism led by articles describing mutations in genes that have a large affect on HDL cholesterol levels through their roles in HDL and triglyceride metabolism. Using this information fro...
متن کاملRare Genetic Variants and High-Density Lipoprotein
Although static plasma concentration of high-density lipoprotein cholesterol (HDL-C), usually measured in the fasting state, is an excellent marker of atherosclerosis risk, its direct causal role in atherogenesis has lately been called into question. Strong evidence refuting a causal protective role for HDL has come from studies of rare genetic variants that affect plasma HDL-C concentrations. ...
متن کاملSubfractions of high-density lipoprotein (HDL) and dysfunctional HDL in chronic kidney disease patients
A number of studies have shown that chronic kidney disease (CKD) is associated with increased risk for cardiovascular disease (CVD). Chronic kidney disease is characterized by significant disturbances in lipoprotein metabolism, including differences in quantitative and qualitative content of high-density lipoprotein (HDL) particles. Recent studies have revealed that serum HDL cholesterol levels...
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ژورنال
عنوان ژورنال: Drugs in Context
سال: 2018
ISSN: 1740-4398
DOI: 10.7573/dic.212546